This international symposium will put into perspective recent advances in the fields of RNA-dependent regulation of gene expression and decoding of messenger RNAs during translation. The symposium is also organized in honor of Eric Westhof in recognition of his scientific activities and institutional actions within the CNRS Institute of Molecular and Cellular Biology and the University of Strasbourg. The themes that have shaped his career and guided the development of the Unit Architecture and Reactivity of RNA and of the labEx NetRNA will be addressed and discussed by several scientists of international stature, including Nobel laureates. We hope you will be able to join us and share ideas and discussions at the Bischenberg Center, near Strasbourg.