Androgen receptor coordinates metabolic and contractile functions of skeletal muscle

Androgens are steroid hormones that affect muscle structure and strength whose action is mediated by the androgen receptor. In a study published in the Journal of Cachexia Sarcopenia and Muscle, the research group coordinated by Dr. Daniel Metzger and Dr. Delphine Duteil, INRT cluster, characterized the effect of the absence of the androgen receptor in skeletal striated muscle fibers, leading to the development of muscle weakness and type 2 diabetes, and identified the underlying molecular mechanisms.