Confirmed Speakers:

• Paul Aliu, Novartis, Switzerland
• Fabiana Arzuaga, University of Buenos Aires, Argentina
• Alta Charo, University of Wisconsin, USA
• Marina Cavazzana, University of Paris Descartes, France
• Kazuto Kato, University of Osaka, Japan
• Kiran Musunuru, UPENN, USA
• Michael S Pepper, University of Pretoria, South Africa
• Pawel Lukow, University of Warsaw, Poland
• Julian März, University of Zürich, Switzerland
• Fyodor Urnov, UC Berkeley, USA

Register now!!! https://us06web.zoom.us/webinar/register/WN_HzSlttoAQh6wtA_xPChkmw#/registration

Free for ARRIGE members (€50 annual fee) | €80 for non-members
Travel discount available via AIR FRANCE/KLM – use event code GME60051AF

This event is sponsored by the University of Strasbourg

Appointment at IBMC. Address and information at https://ibmc.cnrs.fr/agenda/seminaire-du-prof-annemarthe-g-van-der-veen-sensing-self-endogenous-dsrna-in-nucleic-acid-immunity/

The third edition of the IMCBio Summer School will take place between June 24 and June 27 in Strasbourg*!

• Experience Sci-fun
• Meet biology experts
• Visit top research facilities
• Assist to scientific lectures
• Participate to social events
• Discover the Alsatian charm
• And have the opportunity of getting 1-month financially supported internship!**

Check the Inserm website to find out about other projects and their videos.

The DELTArget project is funded by the ANR (French National Research Agency), project number ANR-21-CE15-0035-01.

http://www.cercle-gutenberg.fr/titulaires-et-laureats/prix-guy-ourisson-et-autres-prix-jeunes-chercheurs/

Inscription

The third edition of the IMCBio Summer School will take place between June 24 and June 27 in Strasbourg*!

• Experience Sci-fun
• Meet biology experts
• Visit top research facilities
• Assist to scientific lectures
• Participate to social events
• Discover the Alsatian charm
• And have the opportunity of getting 1-month financially supported internship!**

 Salle de conférence Léon Hirt

Institut de biologie moléculaire des plantes (IBMP)

12 rue du Général Zimmer

67000 Strasbourg

In a groundbreaking study published in Communications Biology, the ERA-NET SusCrop “BioProtect” consortium, led by Manfred Heinlein at IBMP and including Karl-Heinz Kogel (holder of the 2024 Gutenberg Chair at IBMP), along with collaborators from the Universities of Helsinki (Finland) and Bielefeld University of Applied Sciences (Germany), has demonstrated effective control of Magnaporthe oryzae, a major fungal pathogen. The research shows that exogenous treatment of plants with dsRNA targeting fungal genes can activate two complementary mechanisms: sequence-specific RNA interference (RNAi) and a sequence-independent fungal stress response.

For the fifth time in eight years, Professor Thomas Baumert at the Institute for Translational Medicine and Liver Diseases (Unistra/Inserm) has been awarded a prestigious ERC Proof of Concept Grant by the European Union. This new ERC (PACMAN) will enable the researcher and his team to develop an innovative therapeutic approach to treat pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer.

These substances are found in a variety of everyday products, such as food packaging, kitchen utensils and household products. Their properties make them highly persistent, so they end up in the environment. Pollution by PFAS, some of which are highly toxic, is thus affecting the general public.

Michael Ryckelynck and Stéphane Vuilleumier are professors-researchers in biochemistry and microbiology at the CNRS and the University of Strasbourg. They explain this quest for PFAS-eating bacteria." Source = Air Zen Radio

This seminar will take place on January 10, 2025 at 9:15 a.m. in the IBMP seminar room, Strasbourg, France.

Organized by: Dr Dominique Gagliardi

These include EvoCure, a project involving the “Antiviral immunity in insects” team (Carine Meignin et Jean-Luc Imler). This project aims to discover new immune proteins by exploring the evolutionary conservation of immune mechanisms, from bacteria to animals.

Video explanation on https://labex-netrna.cnrs.fr/events/a-team-from-the-netrna-research-cluster-wins-inserms-impact-sante-program/?occurrence=2025-01-08

An article not to be missed! picked up by France Inter

Registrations are open until January 26, 2025 (deadline for creating an account: January 19, 2025) and can be made directly on the competition application: https://imcbio-phdprogram.unistra.fr/

The prize includes start-up training.

Will Radi be the leader of the next start-up to emerge from the team? To be continued!

The speaker will give his seminar at the Amphitheater CRBS, 1 rue Eugène Boeckel, Strasbourg with the title “How Listeria outsmarts its host”.

See the article on the RNA Society website

Dates

    Symposium: 19 and 20 September 2024
    Abstract deadline (for talks): 30 June 2024
    Registration
        Open: 15 April 2024
        Close: 30 June 2024

Fees

    Students: 150 Euros
    Postdocs: 180 Euros
    PIs and senior Researchers: 200 Euros
    Non academics: 300 Euros

(Include: 2 lunches, 4 coffee breaks, a cocktail, and a reusable cup)

In the program

    4 keynote speakers
    6 invited speakers
    13 selected speakers from abstracts. (why not you!)
    2 poster sessions

Read more

He has been invited by Dr. Stephano MARZI, Unit ‘Architecture and Reactivity of arN’, Institute of Molecular and Cellular Biology (IBMC).

This seminar will take place on 14 June 2024 at 11:00, at the IBMC seminar room, Strasbourg, France.

NLRP3 activation in endosomes: From basic mechanisms to disease

Cells in our body are constantly exposed to environmental stressors. Cells have therefore developed an intricate system of proteins that can detect these insults. Once these proteins get activated by them, they eventually induce an inflammatory response. From an evolutionary perspective, inflammation has a beneficial role as it eliminates these stressors and facilitates the repair of tissue damage caused by them. However, if inflammation persists, it can also have detrimental effects.

Our project, supported by the 'Chaires d’excellence,' centers on investigating a specific protein known as NLRP3, capable of detecting a diverse array of seemingly unrelated environmental stressors. We recently made a discovery that these stressors share a common trait: they all disrupt the composition of a specific cellular compartment known as the endosome. In fact, NLRP3 is recruited to these “stressed” endosomes thereby initiating inflammation. The understanding of this mechanism could potentially explain low-grade inflammation observed in different human diseases including obesity-associated diabetes.

Our discovery created a new research axis in the laboratory that opened fundamentally novel scientific questions. Answering them in a more comprehensive manner constitutes a very ambitious endeavor that requires state-of-the-art experimental tools and collaborations at the international level. A project of this dimension clearly requires substantial funding on a long-term basis. The “Chaire d’excellence” will provide the necessary support that will increase our international visibility at the interface of cell biology and immunology.

*************

Albert WEIXLBAUMER, CoTransSplice Project

Decipher the coupling between mRNA splicing and gene transcription

Albert WEIXLBAUMER is one of the laureates of the ANR Chair d’excellence program. The generous funding will support his research group for 5 years, as they tackle a fundamental question: how is the coordination between transcription and splicing achieved in humans? In gene expression, transcription yields pre-mRNA, a transient DNA copy, which subsequently undergoes splicing to excise non-coding segments, resulting in mature mRNA. The process of splicing is pivotal for human proteomic diversification, as various mature mRNAs can be produced from a single pre-mRNA. Notably, splicing occurs concomitantly with transcription and is regulated by the transcription machinery. Yet, this intricate relationship remains poorly understood and will be the focus of the funded project. Ultimately, this endeavor aims to enhance our comprehension of the interplay between transcription and splicing, elucidating how humans diversify their proteome and how dysregulation of these processes may contribute to disease.

This call for applications is open to young researchers, from any field of research relating to plant mitochondria or chloroplasts, and having the capacity to lead a research team at the highest scientific level. Proposals relating to the scientific priorities of the MitoCross consortium will be preferentially considered, as well as those from candidates bringing new skills and/or developing new photosynthetic organisms' models.

Researchers applying for permanent positions (CNRS / researcher or lecturer-researcher at the University of Strasbourg) during the recruitment campaigns of 2024 are eligible for this funding program. Applicants are also invited to submit funding requests to other national and international calls (ERC, ANR JCJC, ATIP-Avenir, CPJ etc.), compatible and cumulative with these research chairs.

• Duration

These chairs are funded for a period of up to four years, with possible extension within the limit of the aid allocated.

• Funding

The aid allocated to each chair is 400 k€. The amount of funding may include the salary of the chair holder and expenses related to the installation and operation of a research team (salary of a post-doctoral fellow or of a technician, purchase of small equipment, etc.), as well as operational costs.

• Contact

Expressions of interest including a curriculum vitae (2 pages maximum) and a brief description of the scientific program (5 pages maximum) should be sent to

Philippe Giegé: philippe.giege[at]ibmp-cnrs.unistra.fr

et à

Ivan Tarassov: i.tarassov[at]unistra.fr